BPC-157, or Body Protection Compound 157 is a synthetic peptide modeled after one found naturally in the human stomach.
Mechanism of action of BPC-157 can be shown by the example of supporting the treatment of a torn Achilles tendon.
At first, the body will respond with inflammation, during which the body will seek to maintain stable internal conditions by Providing platelets, white blood cells, antibodies, enzymes and other components needed for wound healing and stopping a possible infection.
Then our body will start tissue reconstruction through the process of cell migration, which moves healthy cells to the site of injury. In this particular injury, it should be noted that Achilles tendon is largely composed of extracellular matrix (the building material in the body) and tendon fibroblasts.
After administration of BPC 157, granulation tissue or new connective tissue grows faster along with tendon fibroblasts at the site of injury so that the regeneration process can take significantly less time and be more effective.
In addition, the BPC-157:
- Accelerates the regeneration of tendons and ligaments[1] [2]
- Promotes tendon-to-bone healing effective enough, that can actually "successfully replace current reconstructive surgical methods" [3]
- increases intestinal regeneration to the point where the negative effects of NSAIDs (non-steroidal anti-inflammatory drugs, i.e. ibuprofen/paracetamol) on the intestines can be reversed. [4] In addition, it was stated that "no other substance tested in this regard has presented similar effects."
- Repairs damage caused by inflammatory bowel disease (IBD) [5]. and strengthens intestinal regeneration
- has an anti-inflammatory effect[6]
- has an antidepressant effect by increasing the release of serotonin [7]
- has hepatoprotective effects [8].
Is BPC-157 safe to use?
BPC-157 is a peptide that has been extensively studied for nearly 30 years, and was initially used mainly by injection through which, through errors in correct application, skin redness, swelling, or itching could occur. In rare cases, occasional nausea, bloating and deregulation of intestinal peristalsis of minor severity may occur in hypersensitive individuals, probably through the effects of BPC on the intestines.
It has been proven in clinical trials, that BPC 157 is safe In both inflammatory bowel diseases (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice and Has no toxic effects on the human body. [4]
1 - https://pubmed.ncbi.nlm.nih.gov/21030672/
2 - https://pubmed.ncbi.nlm.nih.gov/20225319/
3 - https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.20096
4 - https://pubmed.ncbi.nlm.nih.gov/22950504/
5 - https://pubmed.ncbi.nlm.nih.gov/17713731/
6 - http://www.jpp.krakow.pl/journal/archive/12_09_s7/pdf/115_12_09_s7_article.pdf
7 - https://pubmed.ncbi.nlm.nih.gov/15531385/
8 - https://pubmed.ncbi.nlm.nih.gov/7901724/
