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Posted on: 29 December 202217 April 2024

How to take care of your memory? Semax peptide and other methods to improve memory

Human memory is unlimited. This means that a person is capable of storing and processing an infinite amount of information. How efficiently our brain works, however, depends significantly on ourselves - how we support our thought processes. The nervous system needs improvement in the form of, among other things, brain training, as well as supplements to improve our cognitive and thinking abilities. Among them is Semax peptide, which has been researched by external research centers.

What is Semax peptide?
How to take Semax peptide?
What else can you do to remember better and more?

What is Semax peptide?

Semax peptide is the final fragment of an analog of ACTH, the pituitary peptide hormone, whose increase in blood levels is one of the human body's first reactions to stress. The supplement Semax peptide is composed of proteins naturally found in the human body, so it is well absorbed by the body and is also very effectively absorbed.

According to research, Semax peptide Has a beneficial effect on the protection of the nervous system and improves its work. It also has the effect of improving memory and concentration. This is because, among other things, it reduces the death of cholinergic neurons and neurons located in the forebrain. Thanks to melanocortin receptors, it activates the serotonin and dopamine systems, which ultimately results in better cognitive functioning.

How to take Semax peptide?

A package of Semax peptide contains a vial of powder, a vial of water and an atomizer. The two substances should be combined by pouring the water into the powder. Mix the whole thing so that a uniform consistency is formed. In this way you get 6 ml of 1% solution. This corresponds to 42 puffs of 1.4 mg of Semax peptide.

To get the desired results and improve thinking and memory processes, use the supplement according to Semax dosage recommendations. Take the peptide for a minimum of 2 weeks twice a day - in the morning and in the evening, two puffs each. After this time, once you see an improvement, take the peptide prophylactically at a dose of 2 puffs in situations that require you to work harder on your brain and nervous system.

And where buy Semax peptide? You will order it on our website. The product is shipped as early as the second business day after payment.

What else can you do to remember better and more?

Semax peptide will allow you to improve the memory processes that take place in your body. This is a very big support for it, as it allows you to make changes at the cellular level. However, to improve and maintain the results achieved, work on your memory. These, in turn, are techniques that you can use every day without additional cost or investment.

Gymnastics for the brain - the more intensively you use it and force it to work harder, the better it functions. The human brain is very malleable, so you can develop it through specific exercises. Brain training involves solving various types of puzzles and crossword puzzles. Memory games will also work well, as well as games for memorizing sequences of numbers and letters.
Vitamin diet - Your brain also needs nutrition, as does your entire body. A diet rich in the right vitamins and nutrients allows for the proper production of neurotransmitters responsible for sending impulses between neurons. These include vitamins C, E and B vitamins, as well as potassium, phosphorus, magnesium and iron.
Physical activity - the brain gets oxygenated during physical activity, especially those practiced outdoors. Moreover, any sport forces the brain to analyze sequences of successive movements, which is conducive to improving cognitive abilities.
Sleep - the human body needs it for regeneration. This is the time for rest, which is also necessary for the brain after a day of intense work. During sleep, it assimilates and organizes new information, sorts and arranges it accordingly, so that it is easier to find it later. In addition, the information that we no longer need is removed from the brain to free up space for new information. It is recommended that sleep should last about 8 hours. However, this is an individual issue and you may find that 6-7 hours of sleep is enough for you. Watch your body and listen to its needs.

Memory is written into our genetic code. Everyone has it, however, it is up to ourselves how we use its potential. Of course, there are factors beyond our control that adversely affect our thought processes, such as illness. Nevertheless, you can do a lot for your memory. Support it from the inside with Semax peptide supplement and take care of your good daily habits to remember better and remember more.

Posted on: 4 September 202117 April 2024

What is Semax?

Semax, a heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro, is an agent from Russia used to prevent and treat circulatory disorders.

It is listed on the list of important and necessary medicines by the Russian government [1]. Despite the use of semax in hospital treatment in Russia, it is available in pharmacies without a prescription. This is because despite numerous studies on humans and rats, no side effects have been demonstrated. Additionally, does not appear on the World Anti-Doping Agency's (WADA) lists of banned agents.

More than 20 years of intensive research by Russian scientists on the effects of Semax - on the body have shown that it is useful and applicable:
- w post-stroke treatment and to reduce the risk its occurrence [2], [3],
- at transient ischemic attack (TIA) via neuroprotective effects In cases of cerebral hypoxia, [4].
- in cases memory and concentration disorders, [5]
- at ulcers In the gastrointestinal tract, [6]
- at optic nerve disease [7]
- at strengthening the immune system response stress-induced [8].

What mechanisms of action has Semaks?

After 1 - Increases BDNF concentration in the brain [9] which can directly translate into better focus and cognitive abilities. BDNF is crucial and essential for cognition, synaptic plasticity and neuronal viability. Low BDNF concentrations can exacerbate depression and anxiety disorders, so Semax by raising BDNF concentrations should reduce the risk of these, or exacerbate them.

After 2 - Reduces the breakdown of enkephalins, which are opioid-like substances naturally found in our brains responsible for mood and pain relief, which can translate into better mood in chronic pain. [10]

After 3 - Has neuroprotective effects [11] that is, it protects the nervous system from oxidative damage. It reduces the risk of onset and worsening of neurodegenerative diseases and inhibits the adverse effects of stress on the nervous system.

After 4 - Influences the expression of genes related to the immune system and cardiovascular system [12] which (if supported by more studies on large groups of people) may help prevent pathologies related to these systems.

What it looks like in practice?

In a number of cases, the use of semax as an intranasal spray in volunteers resulted in a sensation of sharpened sensitivity to colors, improved focus and mood. The effect can be felt a few minutes after use.
The direct, subjective effects of semax were most noticeable in those complaining of concentration problems, irritability, lack of motivation and chronic fatigue.

Is Semax safe for humans?

In a Study on over 200 people with reduced cerebral blood flow [13], therapy Semaxem helped reduce overall brain damage to patients and reduce the risk of potential future strokes. In addition, the study showed that in all Semax patients were "well tolerated" and showed no side effects.

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Posted on: 3 September 202127 June 2024

What is Selank?

Selank, which is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, is a synthetic anlaog of tufisin with many potentially beneficial properties.

Selank is closely related to another nootropic agent, Semaxem , developed by the Institute of Molecular Genetics in Russia. This substance is now available in Russian and Ukrainian pharmacies. In addition, does not appear on the World Anti-Doping Agency's (WADA) lists of banned agents.

How does selank work?

Selank modulates IL-6 shedding, and affects T-type cytokine levels, regulates serotonin and other monoamine neurotransmitter metabolism, and increases BDNF factor in the hippocampus.

Drawing on more than 20 years of research history on the seltzer we can observe:

1) potential anti-anxiety effects - A study of 60 people with generalized anxiety syndrome using selank during therapy reported medium nootropic effects and significant anti-anxiety effects. In addition, another study used selank to optimize the treatment of generalized anxiety syndrome in people using fenazepam (a powerful drug of the benzodiazepine genus that should not be used without the knowledge of the referring physician) and compared its effect to a group that was treated with fenazepam alone. Those additionally using selank experienced significantly fewer side effects from fenazepam and increased comfort in life.

2) possible improvement in the speed of remembering and learning - In a study on mice, it was shown that selank can improve learning speed within 3 days. In addition, mice consuming selank showed fewer signs of stress and moved faster.

3) Can help in the treatment of neurodegeneration of the brain -. in a study on mice with impaired brain function by administering 6-hydroxydopamine (a neurotoxin that selectively loads the catecholaminergic system) for the first three days after birth. Selank restored cognitive function to the brains of the mice to which it was administered.

4) Can protect the liver - In a study on chronically stressed mice, selank increased antioxidant activity in the liver and restored its normal function.

5) can improve memory - In studies in mice and monkeys, selank stabilized memory pathways within 30 days of starting use.

6) can strengthen immunity - in one study boosted IL-6 production in depressed patients, which may translate into better immunity, but in another, despite similar findings, showed no improvement against viral infection.

7) may help in people with withdrawal syndrome - In a study on rats in which they were given 10% ethanol solution as their sole source of water for 24 weeks, selank helped reduce alcohol withdrawal anxiety in rats within 48 h of withdrawal.

What does it look like in practice?

Users of selank may experience greater focus, calm (in case of a stressful situation), clarity of thought, mood enhancement and in a smaller number of cases increased motivation to take action.

1 - https://pubmed.ncbi.nlm.nih.gov/25176261/
https://pubmed.ncbi.nlm.nih.gov/30335073/

2 - https://pubmed.ncbi.nlm.nih.gov/14552529/

3 - https://www.ncbi.nlm.nih.gov/pubmed/18683497

4 - https://pubmed.ncbi.nlm.nih.gov/28853100/

5 - https://pubmed.ncbi.nlm.nih.gov/20919548/
https://pubmed.ncbi.nlm.nih.gov/18727417/

6 - https://pubmed.ncbi.nlm.nih.gov/18577961/

7- https://pubmed.ncbi.nlm.nih.gov/24913576/

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Posted on: 2 September 2021

Bpc 157

BPC-157, or Body Protection Compound 157 is a synthetic peptide modeled after one found naturally in the human stomach.

Mechanism of action of BPC-157 can be shown by the example of supporting the treatment of a torn Achilles tendon.

At first, the body will respond with inflammation, during which the body will seek to maintain stable internal conditions by Providing platelets, white blood cells, antibodies, enzymes and other components needed for wound healing and stopping a possible infection.

Then our body will start tissue reconstruction through the process of cell migration, which moves healthy cells to the site of injury. In this particular injury, it should be noted that Achilles tendon is largely composed of extracellular matrix (the building material in the body) and tendon fibroblasts.

After administration of BPC 157, granulation tissue or new connective tissue grows faster along with tendon fibroblasts at the site of injury so that the regeneration process can take significantly less time and be more effective.

In addition, the BPC-157:

- Accelerates the regeneration of tendons and ligaments[1] [2]
- Promotes tendon-to-bone healing effective enough, that can actually "successfully replace current reconstructive surgical methods" [3]
- increases intestinal regeneration to the point where the negative effects of NSAIDs (non-steroidal anti-inflammatory drugs, i.e. ibuprofen/paracetamol) on the intestines can be reversed. [4] In addition, it was stated that "no other substance tested in this regard has presented similar effects."
- Repairs damage caused by inflammatory bowel disease (IBD) [5]. and strengthens intestinal regeneration
- has an anti-inflammatory effect[6]
- has an antidepressant effect by increasing the release of serotonin [7]
- has hepatoprotective effects [8].

Is BPC-157 safe to use?

BPC-157 is a peptide that has been extensively studied for nearly 30 years, and was initially used mainly by injection through which, through errors in correct application, skin redness, swelling, or itching could occur. In rare cases, occasional nausea, bloating and deregulation of intestinal peristalsis of minor severity may occur in hypersensitive individuals, probably through the effects of BPC on the intestines.

It has been proven in clinical trials, that BPC 157 is safe In both inflammatory bowel diseases (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice and Has no toxic effects on the human body. [4]

1 - https://pubmed.ncbi.nlm.nih.gov/21030672/
2 - https://pubmed.ncbi.nlm.nih.gov/20225319/
3 - https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.20096
4 - https://pubmed.ncbi.nlm.nih.gov/22950504/
5 - https://pubmed.ncbi.nlm.nih.gov/17713731/
6 - http://www.jpp.krakow.pl/journal/archive/12_09_s7/pdf/115_12_09_s7_article.pdf
7 - https://pubmed.ncbi.nlm.nih.gov/15531385/
8 - https://pubmed.ncbi.nlm.nih.gov/7901724/

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Posted on: 1 September 2021

GHK-Cu

Human copper-binding peptide GHK-Cu (glycyl-l-histidyl-l-lysine) is a small, naturally occurring tripeptide present in human plasma that can also be released from tissues in the event of injury.

Since its discovery in 1973, GHK-Cu has established itself as a powerful protective and regenerative ingredient that is now widely used in skin and hair creams, cosmetic products and intranasal formulations.

In light of a wide-ranging 2018 publication [1] has many biological activities, of which all, according to current knowledge, appear to be beneficial to health.

How does GHK-Cu work?

GHK-Cu:
- stimulates The growth of blood vessels and nerves,
- increases collagen synthesis,
- increases synthesis of collagen elastin and glycosaminoglycans,
- supports The action of dermal fibroblasts,

Capability GHK-Cu to improve tissue repair has been demonstrated in the case:
- skins,
- connective tissues lungs,
- tissues bone,
- livers,
- linings stomach.

As a result, the GHK-Cu is able to:

- tighten loose skin And reverse the thinning of aging skin,

- stimulate skin protective proteins,

- Improve the firmness, elasticity and clarity of the skin,

- reduce fine lines, wrinkle depth and improve the structure aging skin,

- smooth rough skin

- reduce mottled discoloration, stains and skin lesions

- improve overall appearance of the skin

- stimulate wound healing,

- protect skin cells against radiation UV,

- reduce inflammation and free radicals,

- increase hair growth and thickness,
- increase hair follicle size,

The aforementioned study [1] also found that. GHK has a strong protective effect For cells, such as: numerous anticancer activities i anti-inflammatory, including lung protection i Restoring fibroblasts of chronic obstructive pulmonary disease (COPD)!

GHK-Cu He is also responsible for:
- particle suppression, which are considered to be accelerating diseases of aging, such as NFκB,
- action anti-anxiety, painkillers i anti-autoimmunization,
- DNA repair,
- Activation of cell purification by the proteasome system.

Does GHK-Cu have established side effects?

The only reported cases of side-effect findings occurred in amounts below 1% humans and were strongly correlated with the specific mode of administration of the peptides - injection.

The most common side effect was red coloration and pain around the injection site.
Other noted side effects include:
- increase in appetite
- bloating
- sleepiness

None of the clinical trials found any deterioration in health after the use of GHK-Cu

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/

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Posted on: August 24, 2021

What are peptides?

What are peptides?

Peptides are amino acids linked together by a peptide bond. They are organic compounds, often with a very delicate structure.

Peptides up to 10 amino acid residues long are called oligopeptides, and those with a longer chain are called polypeptides, or proteins (the kind we eat in food).

When and where are peptides used?

Peptides are widely used:
– w kosmetologii (szczególnie w kremach ujędrniających/odżywiających skórę),
– w salonach urody dzięki swojemu działaniu anty-ageingowemu,
– jako terapia pomocnicza przy udarach mózgu,
– jako leki w przypadku poparzeń, lub uszkodzeń tkanek
– przy wspomaganiu regeneracji dla osób po operacjach i sportowców
– u osób z uszkodzeniami narządów wewnętrznych (np.: marskość wątroby, niewydolność nerek, POChP)

Each of the above examples refers to different peptides. In order to know which peptide to choose for your case, you need to learn about the specifications of the agent in question.

Are peptides hormones?

Peptides ARE NOT hormones, but there are hormones with a peptide structure.

The most important of these are:
– insulina
– oksytocna
– ACTH
– sekretyna
– angiotensyna

Are peptides safe?

Peptides are uncomplicated organic compounds very similar to naturally occurring proteins in the human body, so there are no health-threatening side effects when peptides are used properly.

Are peptides allowed for athletes?

In the case of professional sports, the Olympic Games, or other events supervised by anti-doping committees, it is always necessary to follow the rules imposed before WADA (World Anti Doping Agency) and, in particular, review the list of banned substances published by them every year.

As of 2021, none of the peptides in our portfolio appear on this list.

What types of peptides exist?

Peptides can be divided into 3 types:

– peptydy sygnałowe – potrafią inicjować procesy wewnątrzkomórkowe, co w zależności od peptydu może zwiększać regenerację/przebudowę włókien mięśniowych/fibroblastów, lub zwiększyć syntezę kolagenu i elastyny co może się przełożyć na ujędrnienie skóry. Przedstawicielem tego typu peptydów jest Hexapeptyd-10, którego od lat można zauważyć w kosmetykach do pielęgnacji skóry.

– peptydy transportujące substancje aktywne – pomagają trafić większej ilości danych składników odżywczych/substancji organicznych do danej części tkanki (w zależności od danego peptydu). Idealnym przykładem takich peptydów są peptydy miedzowe (m. in. GHK-Cu w naszej ofercie), które świetnie regenerują i rozjaśniają blizny, rozstępy oraz przebarwienia na skórze.

– neuropeptydy – są to peptydy wykorzystywane przez neurony do komunikacji między sobą oraz do regulacji różnorodnych procesów biologicznych, między innymi metabolizmu, uczenia się, pobierania pokarmu, czy reprodukcji. Świetnymi przykładami tego rodzaju peptydów są Semax oraz Selank, które znajdują się w naszej ofercie.

Each of the above types of peptides contains many subcategories that focus on a different targeted action. In order to know which peptide to choose for your case, it is necessary to learn about the specifications of a particular agent.

Chcesz dowiedzieć się więcej o konkretnych peptydach w naszej ofercie? Kliknij w link obok danego peptydu!

Semax

Selank

BPC-157

GHK-Cu

Epitalon

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Posted on: 29 July 2021

Epitalon

Epitalon is a synthetic peptide with the amino acid sequence: Ala-Glu-Asp-Gly, which is based on the natural peptide present in the pineal gland - epithalamin.

Its action is a potential slowing down the aging of the human body.

How does epithalon work?

To understand the workings of the epithalon at the outset, it is necessary to look at the main theory of "aging of the body." i.e. telomere shortening.

Telomeres Are stretches of DNA located at the end of chromosomes. They protect and stabilize our DNA during cell division (including, for example, regeneration).

Telomere shortening, is a process that occurs in every human being and inevitably leads to the end of a cell's life cycle and increases the risk of cancer. The "older" the cells, the lower the efficiency of cell division, and thus the weaker the regeneration.

Telomerase it's quite complex An enzyme that stimulates telomere elongation, i.e., it works the opposite of aging processes.

Epitaloninduces Expression of the catalytic subunit, telomerase enzymatic activity and telomere elongation, which may result from reactivation of the telomerase gene in somatic cells and indicates the possibility of extending the life of the cell population and the entire organism. [1]

2020 study [2] confirms the effect of epithalon on:
- regulation of pineal gland function
- Extension of cell viability in animals and humans (which translates into longer life)
- Reduce the chances of cancerous changes in cells

Additionally epitalon :
-stimulates the pineal gland to produce melatonin at night,which can translate into better sleep
- works neuroprotective
- works anti-inflammatory
- may help with retinal degeneration

Is epitalone safe?

Epitalon is not yet approved by the FDA, but has gone through a period of testing on animals, isolated human cells, and is now at the stage of conducting tests of its effectiveness on humans. To date no side effects of its use have been noticed or identified.

Research:
1 - https://pubmed.ncbi.nlm.nih.gov/12937682/
2 - https://pubmed.ncbi.nlm.nih.gov/12937682/

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Posted on: 29 July 2021

Noopept

Noopept, czyli ester etylowy N-fenyloacetylo-L-proliloglicyny to syntetyczna cząsteczka powszechnie uważana za należącą do klasy racetamów (mimo, iż brakuje mu szkieletu 2-okso-pirolidyny).

Został on wytworzony w 1996 roku [1] na bazie endogennego (czyli wytwarzanego naturalnie wewnątrz naszego organizmu) neuropeptydu cyklopropyloglicyny i wykazuje działanie przeciwlękowe i łagodnie psychostymulujące, jednocześnie wspomagając umiejętności poznawcze i pamięć [2].
Noopept według popularnego niemieckiego artykułu [3] jest około 1000 razy bardziej efektywny niż inny, popularny i podobnym do niego nootropik – piracetam. Jednakże nowe badania z 2011 roku sugerują, iż jego działanie może być około 200-50000 silniejsze od piracetamu w dawce 1;1, w zależności od danego przypadku (jej/jego problemów z pamięcią, niemożnością skupienia się, zaburzeń umiejętności poznawczych). Oznacza to, iż wystarczy (0,2mg/kg m.c.) by uzyskać podobny efekt do dawek piracetamu (400mg/ kg m.c.).

Czy noopept jest bezpieczny?

W badaniu porównawczym (chociaż obie terapie były ogólnie dobrze tolerowane) odnotowano 1,8-krotnie mniej skutków ubocznych związanych z 20 mg Noopeptu w porównaniu z 1200 mg Piracetamu [3]. Warto nadmienić, iż obie terapie były skuteczne w zmniejszaniu objawów uszkodzenia funkcji poznawczych.
Jak na substancję chemiczną, która ma tak znaczące działanie, skutki uboczne zgłaszane przez osoby przyjmujące noopept są niewielkie, jeśli w ogóle się pojawiają. Niektóre osoby zgłaszają jednak skutki uboczne, takie jak drażliwość, nudności lub bezsenność, jeśli są przyjmowane zbyt blisko snu.

Jak działa noopept?

Noopept przede wszystkim zwiększa ekspresje mRNA, przez co zwiększa stężenia NGF (czynnik wzrostu nerwów o budowie peptydowej) oraz BDNF (neurotroficzny czynnik pochodzenia mózgowego). Dzięki temu występuję nasilenie neurogenezy w hipokampie, który poza wymienionymi wcześniej korzyściami może szczególnie pomóc w depresji.

Mimo podnoszenia stężenia NGF oraz BDNF noopept nie buduje tolerancji, a nawet jego działanie zwiększa się wraz ze stosowaniem, lecz efekty są zauważalne już po pierwszym podaniu.

Badanie z 2010 roku sugeruje, że wzrost hamowania tonicznego w hipokampie może być związany z obserwowanymi działaniami przeciwlękowymi Noopeptu [5].
Dwa możliwe mechanizmy działania na rzecz wzmocnienia funkcji poznawczych to uwrażliwiający wpływ na procesy acetylocholiny lub indukcja produkcji neurotrofin, z których oba teoretycznie zwiększają tworzenie pamięci, dzięki czemu noopept może:

- wyraźnie poprawić pamięć i usprawnić proces uczenia się
– działać przeciwlękowo
– redukować depresję
– działać neuroprotektywnie (ochrania układ nerwowy przed neurodegeneracją, czyli niszczeniem komórek nerwowych)
- zwiększać neuroplastykę mózgu
– rozjaśniać myślenie i redukować zmęczenie psychiczne

[1]https://www.academia.edu/957372/Synthesis_and_antiamnesic_activity_of_a_series_of_N_acylprolyl_containing_dipeptides
[2] https://pubmed.ncbi.nlm.nih.gov/19234797/
[3] https://pubmed.ncbi.nlm.nih.gov/12596521/
[4] https://pubmed.ncbi.nlm.nih.gov/21414388/
[5] https://pubmed.ncbi.nlm.nih.gov/20382202/